Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage
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چکیده
منابع مشابه
Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage
Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine angle. Ninety-five percent of people with VS present with sensorineural hearing loss (SNHL); the mechanism of this SNHL is currently unknown. To establish the first model to study the role of VS-secreted factors in causing SNHL, murine cochlear explant cultures were treated with human tumour secretions from thirtee...
متن کاملExtracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.
BACKGROUND Vestibular schwannoma (VS) is a tumor of the vestibular nerve that transmits balance information from the inner ear to the brain. Sensorineural hearing loss occurs in 95% of patients with these tumors, but the cause of this loss is not well understood. We posit a role of VS-secreted extracellular vesicles (EVs) as a major contributing factor in cochlear nerve damage. METHODS Using ...
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OBJECTIVE This article highlights the clinical presentation and management issues of unilateral vestibular schwannomas in children. We demonstrate how the presentation differs from neurofibromatosis type 2 (NF2) and from adult unilateral vestibular schwannomas. STUDY DESIGN This article is composed of a series of three cases and a literature review. SETTING The study was performed at a univ...
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BACKGROUND Gustatory dysfunction associated with vestibular schwannomas (VS) is a poorly represented clinical presentation. MATERIALS AND METHODS One hundred and forty-nine cases operated from 1997 to 2005 where at least six-month follow-up was available were included. All patients were tested for taste sensations using four modalities of standard taste solutions. Apart from the taste sensati...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep18599